Exploring the Anti-Anxiety Potential of Green-Synthesized Silver Nanoparticles from Abies pindrow Royle in a Rodent Model

Author(s)	Ms. Shagun Choudhary, Ms. Priyanka Thakur, Ms. Shivani Dixit
Country	India
Abstract	Anxiety is a common and often disabling mental health issue affecting millions globally. Traditional plant-based remedies have gained attention as safer alternatives to conventional medications. In this study, we investigated the anti-anxiety potential of biosynthesized silver nanoparticles (Ag-NPs) derived from Abies pindrow Royle leaf extracts. Using a green synthesis method, Ag-NPs were prepared and characterized. Their effects were evaluated in a rodent model of anxiety using behavioral tests (Elevated Plus Maze), biochemical markers of oxidative stress, and brain histology. The results demonstrated that Abies pindrow-derived Ag-NPs significantly reduced anxiety-like behaviors, lowered oxidative stress levels, and showed protective effects on brain tissues. These findings suggest that green-synthesized Ag-NPs from Abies pindrow Royle may represent a promising natural therapeutic approach for managing anxiety.
Keywords	Anxiety, Abies pindrow Royle, silver nanoparticles, green synthesis, oxidative stress, elevated plus maze
Field	Medical / Pharmacy
Published In	Volume 6, Issue 5, September-October 2025
Published On	2025-09-11
DOI	https://doi.org/10.63363/aijfr.2025.v06i05.1307
Short DOI	https://doi.org/g93rm5

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