Unexplained Recurrent Pregnancy Loss: Decoding  the Enigma and Exploring Pathways to Hope

Author(s)	Dr. Astha Chakravorty, Dr. Waseeb Andrab
Country	India
Abstract	Abstract Introduction - Unexplained recurrent pregnancy loss (URPL) is a complex and distressing condition defined by the loss of two or more pregnancies before 24 weeks of gestation, without identifiable causes despite comprehensive evaluation. Affecting approximately 1% of reproductive-aged women, URPL poses significant diagnostic and therapeutic challenges. Causes & Mechanisms - Potential contributing factors include genetic anomalies, uterine structural abnormalities, hormonal imbalances, and immune system dysregulation, particularly involving regulatory T cells (Tregs) and natural killer (NK) cells. Diagnosis - Diagnostic approaches encompass genetic testing, hormonal and metabolic screening, immunological assessments, and advanced uterine imaging. Management - Management strategies range from lifestyle modifications and medical interventions to supportive care and emerging immunological treatments. Conclusion - This article provides a detailed overview of the current understanding, diagnostic techniques, and treatment options for URPL, emphasizing the importance of a multidisciplinary approach in improving pregnancy outcomes for affected women
Field	Medical / Pharmacy
Published In	Volume 6, Issue 5, September-October 2025
Published On	2025-10-18
DOI	https://doi.org/10.63363/aijfr.2025.v06i05.1515
Short DOI	https://doi.org/g97nxs

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