Evaluating the Impact of the Endometrial Receptivity  Array (ERA) in Patients with Unsuccessful Transfers of Genetically Normal Embryos

Author(s)	Dr. Astha Chakravorty, Dr. Waseeb Andrab
Country	India
Abstract	Abstract Objective: Challenges in endometrial receptivity can lead to implantation failures. This study assesses the effectiveness of the Endometrial Receptivity Array (ERA) in identifying these challenges in patients with prior failures in euploid blastocyst implantation. The study explores if identifying endometrial factors through ERA could result in actionable insights that improve patient outcomes. Methods: We conducted a retrospective analysis of 88 patients who underwent ERA assessments from 2014 to 2017. We compared the reproductive success of patients undergoing standard frozen embryo transfer (FET) protocols against those who, based on non-receptive ERA results, followed personalized embryo transfer (pET) protocols. Results: Among those who had experienced at least one failed transfer of a genetically normal embryo, 22.5% were found to have timing issues in their window of implantation (WOI), as identified by the ERA, and were thus eligible for pET. Subsequent transfers using the personalized approach showed higher rates of implantation and ongoing pregnancies (73.7% vs. 54.2% and 63.2% vs. 41.7%, respectively), although the differences did not reach statistical significance
Field	Medical / Pharmacy
Published In	Volume 6, Issue 5, September-October 2025
Published On	2025-10-18
DOI	https://doi.org/10.63363/aijfr.2025.v06i05.1516
Short DOI	https://doi.org/g97nxq

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Advanced International Journal for Research