Advanced International Journal for Research

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Analytical Approaches for The Determination of Additives in Drug Formulations

Author(s) Ms. Pravallika Banda, Ms. Saisireesha P, Dr. Suchitra M
Country India
Abstract Pharmaceutical additives, also known as excipients, play a critical role in the formulation, stability, efficacy, and patient acceptability of medicinal products. These substances, including preservatives, stabilizers, coloring agents, sweeteners, and solubilizers, are essential for ensuring drug safety, bioavailability, and shelf-life. The analytical evaluation of pharmaceutical additives has gained significant attention in recent years due to the growing emphasis on drug quality and regulatory compliance. Various analytical techniques, such as chromatographic methods (hplc, gc), spectroscopic techniques (uv-vis, ftir, nmr), and thermal analysis (dsc, tga), are extensively employed for qualitative and quantitative assessment of these additives. this review highlights the importance of analytical approaches in identifying, quantifying, and monitoring pharmaceutical excipients, ensuring adherence to regulatory standards, and preventing potential toxicological risks. additionally, the review discusses current trends, challenges, and advancements in the analytical evaluation of excipients, emphasizing the need for robust, sensitive, and reproducible methods for routine quality control and research applications. Pharmacists who are familiar with these analytical methods are better able to create drug formulations that are both safer and more effective.
Keywords pharmaceutical additives, excipients, analytical techniques, stability, quality control, drug formulation.
Field Medical / Pharmacy
Published In Volume 6, Issue 5, September-October 2025
Published On 2025-10-27
DOI https://doi.org/10.63363/aijfr.2025.v06i05.1719
Short DOI https://doi.org/g99qn4
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