Advanced International Journal for Research

E-ISSN: 3048-7641   •   Impact Factor: 9.11

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 6, Issue 6 (November-December 2025) Submit your research before last 3 days of December to publish your research paper in the issue of November-December.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 6 Issue 6
November-December 2025

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

Innovations in Mucosal Drug Delivery: A Comprehensive Review of Sublingual and Lingual Delivery Devices

Author(s) Prof. Dr. Kamalakkannan V, Mr. Gowrishankar Padmanaban, Kugalur Ganesan Parthiban, Dr. Sangameswaran Balakrishnan
Country India
Abstract Mucosal drug delivery via sublingual and lingual routes is increasingly recognized as a transformative approach in pharmaceutical research, owing to its ability to circumvent gastrointestinal degradation and first-pass hepatic metabolism, thus enabling rapid onset and enhanced bioavailability for a diverse range of drugs. Recent innovations in materials science have yielded advanced formulations including nanoencapsulation, mucoadhesive films, multilayered tablets, and bioinspired carriers, which significantly improve drug stability, solubility, and residence time within the oral cavity. Device engineering has progressed with the development of personalized 3D-printed dosage forms, nanoparticle sprays, and microrobotic pills equipped with microstirrers, offering precise, rapid, and efficient drug release even under challenging mucosal conditions. Additionally, digital health integration is reshaping sublingual and lingual delivery systems through biosensor-enabled smart patches and dose-tracking devices, promoting real-time adherence monitoring and feedback-based dosing for improved clinical outcomes. Commercial products have expanded to include rapidly dissolving tablets, transbuccal sprays, and smart device prototypes for a range of indications, such as acute pain, cardiovascular emergencies, and chronic disease management. Despite these advances, challenges like formulation stability, taste masking, and variable patient compliance remain focal points for future research, driving ongoing improvements in technology, education, and regulatory pathways.
Keywords Mucosal drug delivery, Sublingual devices, Lingual devices, Buccal sprays, Nanocarriers
Field Chemistry > Pharmacy
Published In Volume 6, Issue 5, September-October 2025
Published On 2025-10-30
DOI https://doi.org/10.63363/aijfr.2025.v06i05.1760
Short DOI https://doi.org/g99qns
View / Download PDF File

Share this



E-ISSN 3048-7641
CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

AIJFR DOI prefix is
10.63363/aijfr

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About AIJFR
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us +91-9898-79-39-59 editor@aijfr.com