Epigenetics and Genomics in Personalized Health: Unravelling Mechanisms of Human Diseases

Author(s)	Prof. Dr. Neha Singh, Prof. Dr. R C Gupta, Dr. Indra Pratap Singh
Country	India
Abstract	The convergence of genomics and epigenetics has revolutionized biomedical science by illuminating the molecular underpinnings of health, disease, and individual variability. While the sequencing of the human genome has provided insight into genetic predispositions, the emergence of epigenetic science has revealed how environmental and lifestyle factors dynamically influence gene expression without altering DNA sequences. This review comprehensively explores the interplay between genomic architecture and epigenetic regulation, elucidating their combined roles in disease manifestation, progression, and therapeutic response. We further discuss how personalized health, driven by genomic and epigenetic profiling, is reshaping the landscape of preventive and precision medicine. Emphasis is placed on recent advances in epigenomic technologies, the Lifestylopathy approach, and the ethical implications of genomic personalization.
Keywords	Epigenetics, Genomics, Personalized Health, Lifestylopathy, DNA Methylation, Precision Medicine, Human Disease
Field	Biology > Medical / Physiology
Published In	Volume 6, Issue 6, November-December 2025
Published On	2025-11-20
DOI	https://doi.org/10.63363/aijfr.2025.v06i06.2116
Short DOI	https://doi.org/hbbz7g

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