Advanced International Journal for Research

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A Review on Various Properties of Methamphetamine

Author(s) Ms. Pranali Vijay Patil, Mr. Eashan Padyal, Mr. Raju Dinesh Parmar, Prof. Dr. Ketan Bhutkar, Prof. Dr. Sanjay Chaudhari
Country India
Abstract Methamphetamine is a potent central nervous system (CNS) stimulant belonging to the substituted phenethylamine and amphetamine class of compounds.
Its chemical structure, C₁₀H₁₅N, enables high lipid solubility and rapid passage across the blood–brain barrier, resulting in intense psychostimulant effects.
Pharmacologically, methamphetamine acts primarily by increasing synaptic concentrations of monoamine neurotransmitters dopamine, norepinephrine, and serotonin through the reversal of transporters and inhibition of reuptake mechanisms.
These actions produce heightened alertness, euphoria, and increased energy but also lead to severe neurotoxicity, cardiovascular stress, and addiction potential with chronic use.
Physically, methamphetamine is a white crystalline powder or solid that is soluble in water and alcohol, with a melting point of approximately 170–175°C.
Its optical isomers, d-methamphetamine and l-methamphetamine, differ in potency and pharmacological activity,
the dextro form being more psychoactive. Methamphetamine’s chemical stability and ease of synthesis from common precursors have contributed to its widespread illicit production.
Ongoing research explores its limited medical applications—such as in the treatment of attention deficit hyperactivity disorder (ADHD) and obesity—while highlighting its significant social, health, and neuropsychological consequences.
Keywords Methamphetamine
Field Medical / Pharmacy
Published In Volume 6, Issue 6, November-December 2025
Published On 2025-11-29
DOI https://doi.org/10.63363/aijfr.2025.v06i06.2175
Short DOI https://doi.org/hbdsvk
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