Advanced International Journal for Research

E-ISSN: 3048-7641   •   Impact Factor: 9.11

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Volume 6 Issue 6
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The Role of Nutrition and Dietary Supplements in Management of Chemotherapy-Induced Side Effects

Author(s) Ms. Priti Narayanan Menon, Dr. Shilpa Raina
Country India
Abstract Chemotherapy-induced side effects remain a major clinical challenge, affecting quality of life and treatment compliance in cancer patients. While pharmacological interventions have advanced significantly, nutritional and dietary approaches provide complementary management strategies. This review examines the evidence for nutrition and dietary supplements in mitigating chemotherapy-induced adverse effects. A systematic analysis of 156 peer-reviewed studies (comprising 48 clinical trials with 8,420 participants, 64 animal studies, and 44 in vitro investigations) was conducted to evaluate the efficacy of micronutrients, herbal supplements, and dietary modifications. Results demonstrate that ginger supplementation reduces delayed nausea incidence by 42 percent to 58 percent and improves chemotherapy-induced nausea and vomiting (CINV) related quality of life scores (p less than 0.05). Antioxidant supplementation (vitamins A, C, E, and selenium) significantly decreased chemotherapy-induced toxicity in 18 out of 32 reviewed studies (56 percent efficacy rate), while no studies reported increased toxicity. Nutritional counseling combined with oral nutritional supplements maintained body weight stability and improved nutritional status in 73 percent of cancer patients receiving chemotherapy. Mediterranean dietary patterns and increased protein intake demonstrated protective effects against cancer-related fatigue (p equals 0.02). The cumulative evidence supports integrating evidence-based nutritional interventions as adjuvant therapy in comprehensive cancer management. However, certain high-dose antioxidants require cautious application during specific chemotherapeutic regimens. Future research should focus on personalized nutrition strategies and mechanistic understanding of dietary components in cancer treatment optimization.
Keywords Chemotherapy-induced side effects, Nutritional supplementation, Ginger, Antioxidants, Dietary management, Cancer supportive care, Quality of life
Field Biology > Bio + Chemistry
Published In Volume 6, Issue 6, November-December 2025
Published On 2025-12-03
DOI https://doi.org/10.63363/aijfr.2025.v06i06.2296
Short DOI https://doi.org/hbdssf
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