Advanced International Journal for Research

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Therapeutic Potential of Ficus carica Extract on Protein Levels of Reproductive Tissue in PCOS Induced Mice

Author(s) Ms. Sushmita Dasharath Gurav, Dr. Lata Bhopale, Dr. Tekchand Gaupale
Country India
Abstract Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by hormonal imbalance and ovarian dysfunction. Experimental induction of PCOS using letrozole in animal models provides a reliable approach to study its pathophysiology and potential therapeutic interventions. The present study aimed to evaluate the effect of metformin and Ficus carica plant extract on ovarian and uterine protein levels in letrozole-induced PCOS mice. Female Swiss albino mice of 20 days old were divided into four groups: (1) Control group (2) Letrozole-induced PCOS group, (3) Metformin-treated group, and (4) Plant extract-treated group. PCOS was induced by oral administration of letrozole for 21 days. Following the treatment period for consecutive 21 days, ovarian and uterine tissues were collected, homogenized, and total protein was measured by using standard method with Folin–Ciocalteu reagent using bovine serum albumin (BSA) as the standard. Letrozole-induced PCOS mice showed a significant increase in ovarian total protein concentration compared to control, indicating altered cellular metabolism and tissue remodelling. However, the protein levels in the uterus did not exhibit significant alterations. Both metformin and Ficus carica treatments reduced elevated ovarian protein levels toward normal values. Ficus carica extract exhibited a restorative effect on ovarian protein metabolism comparable to metformin, whereas uterine tissue showed no significant biochemical alteration.
Keywords Protein, Letrozole, PCOS, Ficus carica, Lowry method, Ovary, Uterus
Field Biology > Zoology
Published In Volume 6, Issue 6, November-December 2025
Published On 2025-12-23
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E-ISSN 3048-7641
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