Method Development and Validation of Efavirenz Bulk and Formulation by UV-Spectrophotometric Method

Author(s)	Ms. Lingala Nikhileswari
Country	India
Abstract	The method developed for the determination of Efavirenz in tablet dosage form was found to be simple, sensitivity, precise, selective, rapid and economical. Efavirenz exhibited maximum absorption at 291nm and obeyed Beer’s law in the concentration range of 10-50µg/ml. The proposed method for determination of Efavirenz showed linear regression y=0.181x+1.071 with correlation coefficient (R2) of 0.999. Interday and Intraday studies showed high degree of repeatability of an analytical method under normal operating conditions. The %RSD for precision, which was less than 2%.It indicates that the method is precise. Recoveries obtained do not differ significantly from 100% showed that there was no interference from the common excipients used in tablet formulation indicating accuracy and reliability of the method. The proposed method can be used for drug analysis in routine quality control & method proves to be more economical than the published standard methods.
Field	Medical / Pharmacy
Published In	Volume 6, Issue 6, November-December 2025
Published On	2025-12-31
DOI	https://doi.org/10.63363/aijfr.2025.v06i06.2644
Short DOI	https://doi.org/hbhk4s

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