Advanced International Journal for Research

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Volume 7 Issue 2
March-April 2026

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Evaluation of Antidiabetic Activity of Ethanolic Extract of Mangifera Indica Leaves in Streptozotocin Induced Diabetic Rats

Author(s) Mr. Dr. Battula venkata narasimha, Mr. Dr. Manchineni Prasada Rao, Ms. Prathipati Shiny Grace, Ms. Rangisetty Pujitha Pujitha, Mr. Shaik Adam Shafi, Ms. Tumati Sowmya Sowmya
Country India
Abstract Mangifera indica leaves have been widely used in traditional medicine for the management of diabetes mellitus due to their rich phytochemical composition, particularly mangiferin, flavonoids, and phenolic compounds. The present study aimed to evaluate the antidiabetic activity of Mangifera indica leaf extract using experimental models. The dried leaves were collected, authenticated, shade-dried, powdered, and extracted using a suitable solvent extraction method. Preliminary phytochemical screening confirmed the presence of bioactive constituents such as alkaloids, flavonoids, tannins, glycosides, and phenolic compounds.
The antidiabetic activity was assessed using in vitro methods such as α-amylase and αglucosidase inhibitory assays and/or in vivo streptozotocin-induced diabetic animal models. The extract showed significant dose-dependent inhibition of carbohydrate-hydrolysing enzymes and effectively reduced elevated blood glucose levels in diabetic animals when compared with the standard drug-treated group. A marked improvement was also observed in body weight, lipid profile, and biochemical parameters. The observed activity may be attributed to the presence of mangiferin and other antioxidant phytoconstituents that enhance insulin secretion, improve glucose utilization, and reduce oxidative stress.
Keywords Mangifera indica Mango leaves Antidiabetic activity ,Ethanolic extract Streptozotocin (STZ), Diabetes mellitus, Experimental rats, Hyperglycemia, Blood glucose
Field Medical / Pharmacy
Published In Volume 7, Issue 2, March-April 2026
Published On 2026-04-12
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E-ISSN 3048-7641
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