Advanced International Journal for Research

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Phenotypic Characterization of Virulence Determinants in Colistin-Resistant Klebsiella pneumoniae Clinical isolates

Author(s) Ms. Dipika Priya, Minakshi Gupta, Rashmi, Santosh Kumar Singh
Country India
Abstract Klebsiella pneumoniae is an important opportunistic pathogen causing a broad spectrum of healthcare-associated infections. The development of colistin-resistant strains is an alarming phenomenon given that colistin is often the antibiotic of choice for the treatment of multidrug resistant infections. Assessing the pathogenic potential of these resistant isolates requires knowledge about their virulence profile. This study sought to characterize the phenotypic virulence factors of colistin-resistant K. pneumoniae isolates and examine their relationship with potential increased pathogenicity. A cross sectional study of 22 colistin resistant K. pneumoniae isolates from clinical specimens. Colistin resistance was determined using broth microdilution according to CLSI guidelines. Various virulence factors such as hypermucoviscocity, biofilm formation, gelatinase production, serum-resistance, cell-surface hydrophobicity and type 1-fimbriae were screened. Chi-square or Fisher’s exact test was used for statistical analysis, with significance defined at p 61 years) and intensive care environments, with endotracheal aspirates being the most common source (50%). Presence of serum resistance in all isolates (100%) and presence of type 1 fimbriae in 86.36% showed significant association with a p-value < 0.001. Gelatinase production (63.63%) and biofilm formation (54.54%) were moderately common but not significant. 9.09% isolates manifested hypermucoviscocity and cell surface hydrophobicity which was statistically significant (p < 0.001). The study showed that immune evasion and adhesion mechanisms were one of the major role in promoting colistin resistance especially serum resistant, fimbriae expression in K. pneumoniae strains. The hypermucoviscocity was less prevalent, suggesting that hypervirulence phenotype is not highly associated with it. These finding highlight the importance of ongoing monitoring for growth and spread, as well as additional molecular analysis to address how they relate to resistance versus virulence.
Keywords Phenotypic Characterization of Virulence Determinants in Colistin-Resistant Klebsiella pneumoniae Clinical isolates
Field Biology > Genetics / Molecular
Published In Volume 7, Issue 2, March-April 2026
Published On 2026-04-18
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