Advanced International Journal for Research

E-ISSN: 3048-7641   •   Impact Factor: 9.11

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 7, Issue 3 (May-June 2026) Submit your research before last 3 days of June to publish your research paper in the issue of May-June.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 7 Issue 3
May-June 2026

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar Wiki for Call for Papers WorldCat Zenodo

Phytochemical Profiling and Multifunctional Bioactivity of High-Altitude Kodaikanal Hill Garlic (Allium sativum): Antidiabetic, Antioxidant, Antimicrobial, and Anticancer Evaluation

Author(s) Dr. Razia Muthusamy, Ms. Hemadevi J, Dr. Merlyn Sujatha R
Country India
Abstract Abstract
Diabetes mellitus and oxidative stress-related disorders represent major global health challenges, necessitating the exploration of effective natural therapeutics. This study investigates the phytochemical profile and multifunctional biological activities of high-altitude Kodaikanal Hill garlic (Allium sativum) with a focus on its antidiabetic, antioxidant, antimicrobial, and anticancer potential. Garlic juice extract was characterized using FTIR and GC–MS analyses, revealing the presence of key functional groups and bioactive organosulfur compounds, including trisulfides. The extract exhibited strong antioxidant activity, with a maximum DPPH radical scavenging of 82%, alongside significant ABTS and hydrogen peroxide scavenging effects. In vitro antidiabetic assays demonstrated dose-dependent inhibition of carbohydrate-hydrolyzing enzymes, with IC₅₀ values of 561.15 µg/mL for α-amylase and 686.70 µg/mL for α-glucosidase. The antimicrobial activity showed potent inhibition against pathogenic strains, including Escherichia coli and Staphylococcus aureus, with low minimum inhibitory concentrations. Furthermore, cytotoxic evaluation against MCF-7 breast cancer cells revealed a significant antiproliferative effect with an IC₅₀ of 129 µg/mL, likely mediated through reactive oxygen species (ROS)-induced apoptosis. Overall, the enhanced biological activities observed in Kodaikanal Hill garlic may be attributed to its rich composition of organosulfur and phenolic compounds, potentially influenced by high-altitude agro-climatic conditions. These findings highlight its promise as a natural source for the development of functional foods and therapeutic agents targeting diabetes, oxidative stress, microbial infections, and cancer.
Keywords Garlic, antioxidant, antidiabetic, antimicrobial, organosulfur compounds
Field Biology
Published In Volume 7, Issue 3, May-June 2026
Published On 2026-05-15
DOI https://doi.org/10.63363/aijfr.2026.v07i03.5693
View / Download PDF File

Share this



E-ISSN 3048-7641
CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

AIJFR DOI prefix is
10.63363/aijfr

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 7 Isu 2Cover Page Vol 7 Isu 1Cover Page Vol 6 Isu 6

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About AIJFR
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us +91-9898-79-39-59 editor@aijfr.com