Advanced International Journal for Research

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In-Silico Exploration of Marsilea minuta: ADME Profiling and Potential Neurotherapeutic Applications

Author(s) Mr. Darshan Setty, Dr. Atul Thorat, Dr. Kirankumar B Gudagudi
Country India
Abstract Marsilea minuta (M. minuta), a traditional Ayurvedic medicinal plant, has garnered attention for its potential in treating central nervous system (CNS) disorders. This study employs in-silico computational profiling to evaluate the ADME (absorption, distribution, metabolism, excretion) properties and therapeutic potential of its phytochemicals. Using databases like IMPPAT and predictive tools (SwissADME), we analyzed 12 bioactive compounds (Syringic acid, Vanillic acid,Ferulic acid, 3,4-Dihydroxybenzoic acid, Caffeic acid, 4-Hydroxycinnamic acid, Marsileagenin A, Triacontyl hexacosanoate, beta-Sitosterol, 6-Hentriacontanol, Cholesterol, Stigmasterol), including syringic acid, ferulic acid, and beta-sitosterol. The results highlight phenolic acids as promising candidates due to their drug-like properties (MW <200, moderate lipophilicity, high solubility) and CNS activity, particularly ferulic acid’s BBB permeability. Sterols and lipids exhibited poor bioavailability but demonstrated neuroprotective and anti-inflammatory effects. The study validates traditional uses of M. minuta for epilepsy, cognitive disorders, and anxiety, while identifying molecular targets for future drug development. These findings underscore its potential as a multi-target therapeutic agent for CNS diseases.
Keywords CNS, In-Silico, Ayurveda, Marsilea minuta, SwissADME, Ethnopharmacology, IMPPAT, Phytochemicals, JAIN (Deemed-to-be University)
Field Biology > Bio + Chemistry
Published In Volume 7, Issue 3, May-June 2026
Published On 2026-05-30
DOI https://doi.org/10.63363/aijfr.2026.v07i03.6137
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