Advanced International Journal for Research

E-ISSN: 3048-7641     Impact Factor: 9.11

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 7, Issue 3 (May-June 2026) Submit your research before last 3 days of June to publish your research paper in the issue of May-June.

Isolation and Biological Activity Studies of Some Proteins from Cucurbitaceae Family

Author(s) Mr. SAHIL TRYAMBAK CHIKATE, Prof. Shubham L. Hange, Dr. Surwase K. P
Country India
Abstract Plants belonging to the Cucurbitaceae family represent major agricultural products widely valued for dietary consumption. Beyond traditional nutritional profiles, their agro-industrial processing byproducts—most notably seeds and seed cakes—contain substantial protein reserves that have recently gained massive pharmaceutical and biomedical attention. This final year project focuses on the strategic isolation, sequential biochemical purification, and biological screening of specialized functional proteins harvested from four key representatives of the Cucurbitaceae family: Momordica charantia (Bitter melon), Cucurbita pepo (Pumpkin), Cucumis sativus (Cucumber), and Citrullus lanatus (Watermelon).
In vitro enzymatic inhibition profiling revealed substantial anti-hyperglycemic properties (alpha-glucosidase and alpha-amylase inhibition) and potent anti-inflammatory effects through egg albumin denaturation prevention. Antimicrobial screening showed significant zones of inhibition against Gram-positive bacteria (Staphylococcus aureus) and moderate activity against Gram-negative paths (Escherichia coli). These findings indicate that Cucurbitaceae proteins constitute an exceptional, sustainable source of therapeutic macromolecules capable of being scaled into functional pharmaceutical excipients, neutraceutical components, or targeted biopharmaceuticals.
Keywords Keywords: Cucurbitaceae family, phytochemical composition, therapeutic properties, food, representative species
Field Chemistry > Pharmacy
Published In Volume 7, Issue 3, May-June 2026
Published On 2026-06-01

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