Advanced International Journal for Research

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Volume 7 Issue 5
September-October 2026

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An observational study on differential antidiabetic therapy in the management of chronic kidney disease

Author(s) Dr. Vaishnavi Gonepally, Vemula Jalaja, Gunti Shravani, Penkarla Srilekha, Devunuri Shirisha, Komma Deepthi, Mahankali Rajitha
Country India
Abstract Background information: Chronic Kidney Disease (CKD) is a serious complication of Diabetes Mellitus (DM) that leads to progressive loss of kidney function. Effective glycaemic control and appropriate treatment are essential to delay disease progression and improve patient outcomes. Aim & objectives: To compare the effectiveness of oral antidiabetic drugs, insulin therapy, and combination therapy in CKD patients with Diabetes Mellitus by assessing fasting blood sugar (FBS), serum creatinine levels, and clinical outcomes.
Methodology: A six-month concurrent observational study was conducted among 503 hospitalized CKD patients with diabetes. Data regarding CKD stage, FBS, serum creatinine, and treatment patterns were collected from patient records and analysed to evaluate treatment effectiveness.
Results: Most patients were in Stage V CKD, followed by Stages IV and III. Significant reductions in FBS and serum creatinine levels were observed after treatment. Oral therapy was mainly used in early CKD stages, whereas insulin and combination therapy were more commonly prescribed in advanced stages, resulting in better glycaemic control and renal function.
Conclusion: Appropriate treatment and regular monitoring of blood glucose and renal function improve glycaemic control, slow CKD progression, and enhance clinical outcomes in patients with CKD and Diabetes Mellitus.
Keywords Chronic Kidney Disease, Diabetes Mellitus, Fasting Blood Sugar, Serum Creatinine, Oral Antidiabetic Drugs, Insulin Therapy, Combination Therapy, Glycaemic Control.
Field Medical / Pharmacy
Published In Volume 7, Issue 5, September-October 2026
Published On 2026-09-09
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E-ISSN 3048-7641
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