Advanced International Journal for Research

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Effect of a 12-Week Structured Yogic Intervention on Circadian Rhythm Imbalance in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial

Author(s) Mr. Shyam Tank, Dr. Charu Mehandiratta
Country India
Abstract There exists frequent coexistence of circadian rhythm disorders with polycystic ovary syndrome (PCOS), which worsens symptoms like hyperandrogenism, insulin resistance, and sleep disturbance, however, the use of non-pharmacological interventions that affect biological clock is poorly studied. In this randomized controlled trial, the effects of 12-week yogic intervention program aimed at restoring circadian rhythm disorders in patients with PCOS were studied. Sixty patients aged 18-35 years with PCOS defined according to Rotterdam criteria and exhibiting evening chronotype with disturbed sleep quality were randomly assigned into the yoga (n=30) or control groups (n=30). Patients from the yoga group were subjected to a 60-minute program of asana, pranayama, and meditation, combined with sleep hygiene counseling performed 6 times per week for 12 weeks, while the control group was given general advice regarding the lifestyle. Morning and evening cortisol levels, reproductive hormones, anti-Müllerian hormone, HOMA-IR, body mass index, and menstrual regularity were measured before and after 12 weeks of the intervention, along with chronotype (using the Morningness-Eveningness Questionnaire) and sleep quality (Pittsburgh Sleep Quality Index). Fifty-seven patients finished the study (yoga 28, control 29).
The yoga group compared to the control group had significantly higher levels of morningness (mean difference = 9.2 points, 95% CI 8.0-10.3, p<0.001), improved sleep quality (mean difference = -3.9 points, 95% CI -4.6 to -3.1, p<0.001), restored diurnal cortisol gradient, and significantly lower levels of luteinizing hormone, luteinizing hormone/follicle-stimulating hormone ratio, total testosterone, anti-Mullerian hormone, HOMA-IR and BMI. The regular menstrual cycle was achieved by 64.3% in the yoga group versus 17.2% in the control group (p<0.001). The systematic yogic program successfully normalizes the circadian rhythm and improves endocrine and reproductive status in PCOS women.
Keywords Polycystic Ovary Syndrome, Yoga, Circadian Rhythm, Sleep Quality, Cortisol, Randomized Controlled Trial
Field Medical / Pharmacy
Published In Volume 7, Issue 4, July-August 2026
Published On 2026-08-26
DOI https://doi.org/10.63363/aijfr.2026.v07i04.7497
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