Advanced International Journal for Research

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Successful Twin Pregnancy in a Woman with 46,XY Complete Gonadal Dysgenesis (Swyer Syndrome): a Rare Case Report

Author(s) Dr Shweta Satish Patki, Dr Aditi Mahesh Kunte, Dr Surhud Satish Patki, Dr Satish Manohar Patki, Dr Ujjwala Satish Patki, Dr Shriswaroop Shriprakash Kulkarni
Country India
Abstract 46,XY complete gonadal dysgenesis, also known as Swyer syndrome, is a rare disorder of sex development characterized by female phenotype, presence of Müllerian structures, and non-functional streak gonads. These patients typically present with primary amenorrhea and require assisted reproductive techniques using donor gametes to achieve pregnancy. Reports of twin pregnancies in such women are exceedingly rare.
We report a 32-year-old phenotypic female with primary amenorrhea who was found to have a 46,XY karyotype. Pelvic imaging revealed a normally formed uterus and vagina with streak gonads. Diagnostic hysteroscopy confirmed a normal uterine cavity. Pregnancy was achieved through assisted reproduction using donor gametes. A twin intrauterine pregnancy was diagnosed at 6 weeks scan. Cervical length was found to be on the lower side at NT scan and prophylactic cervical cerclage was performed. At 24 weeks of gestation, the patient developed pregnancy-induced hypertension, which was managed successfully with oral labetalol. The pregnancy progressed without major complications, and an elective cesarean section was performed at 37 weeks of gestation due to twin pregnancy with breech presentation of the first twin. Two healthy female neonates were delivered.
This case highlights the reproductive potential of women with 46,XY gonadal dysgenesis and emphasizes the importance of meticulous antenatal surveillance in achieving favorable outcomes, even in twin gestations.
Keywords Swyer syndrome, 46 XY gonadal dysgenesis, twin pregnancy, donor gametes, primary amenorrhea
Field Medical / Pharmacy
Published In Volume 7, Issue 1, January-February 2026
Published On 2026-01-15
DOI https://doi.org/10.63363/aijfr.2026.v07i01.2942
Short DOI https://doi.org/hbk6z6
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