Advanced International Journal for Research

E-ISSN: 3048-7641   •   Impact Factor: 9.11

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 7, Issue 2 (March-April 2026) Submit your research before last 3 days of April to publish your research paper in the issue of March-April.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 7 Issue 2
March-April 2026

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar Wiki for Call for Papers WorldCat Zenodo

In-vitro Evaluation of Herbo-Synthetic Anthelmintic Oral Thin Film Formulation for Paediatric Use

Author(s) Mr. Uday S H, Dr. Moumita Banerjee, Umaymah Iqbal Sayed, Sonali Behera, Shamma Rai
Country India
Abstract Aims: To Design and assess oral thin strips of an antihelmintic drug for pediatrics.
Study design: The study was designed as an experimental, laboratory-based formulation and assessment.
Place and Duration of Study: Department of Pharmaceutics, Acharya & BM Reddy College of Pharmacy, Bengaluru, conducted over the academic research period.
Methodology: Comparatively Fast-dissolving anthelmintic oral thin films were innovatively produced utilizing the solvent casting process, combining Levamisole Hydrochloride as the active medication and papaya seed extract as a potent natural adjuvant, backed by HPMC K4M as the film-forming polymer and glycerin-sorbitol mix as plasticizers. Explored the Herbo-synthetic synergy of the papaya seed and then the formulation was being prepared. The formulations were analyzed for physicochemical characteristics such as thickness, folding endurance, weight, pH (6.6),tensile strength(0.12 kg/cm²), and disintegration time (2.40 min). Compatibility was validated using FTIR, DSC, and XRD, revealing the lack of significant drug-excipient interactions and amorphous dispersion. Earthworm models were used to assess anthelmintic activity, which included papaya seed extract, pure medication, their combination, and the formed film. Dissolution investigations in phosphate buffer (pH 6.8) measured cumulative drug release (CDR), whereas stability was tested under accelerated circumstances (35 °C ± 2 °C/75% RH).
Results: The combination of Levamisole Hydrochloride and Papaya Seed extract demonstrated synergistic efficacy, causing worm paralysis within 1 minute and death within 1 minute and 10 seconds, quicker than either drug alone. The optimized film delivered >85% drug release in 160 minutes, with cumulative release maintaining steady for 15 days (32-87%). Mechanical and physicochemical parameters suggested that the material was flexible, homogeneous, and disintegrated quickly, making it appropriate for pediatric usage. Stability investigations revealed no significant changes in pH, appearance, drug content, or dissolution profile.

Conclusion: The produced Herbo-synthetic oral thin films have good physicochemical features, synergistic anthelmintic effectiveness, fast drug release, and stability. This innovative paediatric-friendly formulation has the potential to increase compliance, reduce dose frequency, and improve treatment results in helminthiasis.
Keywords Oral thin film, Comparatively Fast-dissolving oral thin film, Anthelmintic, Novel Anthelmintic Combination, Herbo-synthetic, Combination Therapy, Herbo-Synthetic synergy, Pediatric Formulation
Field Medical / Pharmacy
Published In Volume 7, Issue 1, January-February 2026
Published On 2026-01-31
View / Download PDF File

Share this



E-ISSN 3048-7641
CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

AIJFR DOI prefix is
10.63363/aijfr

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 7 Isu 2Cover Page Vol 7 Isu 1Cover Page Vol 6 Isu 6

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About AIJFR
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us +91-9898-79-39-59 editor@aijfr.com