Advanced International Journal for Research

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Study of Fosfomycin Susceptibility in Enterobacteriaceae Isolated from Urine Samples

Author(s) Manjula L, Shams Tabrez, Syed Mohammed Zeemad, Bhagya HM, Dr. Mohammed Yaseen, PT
Country India
Abstract Urinary tract infections (UTIs) are among the most common bacterial infections affecting individuals of all age groups in both community and hospital settings. Enterobacteriaceae, particularly Escherichia coli and Klebsiella species, are the leading causative agents. The rising prevalence of multidrug-resistant uropathogens has limited the effectiveness of commonly used antibiotics. Fosfomycin, a phosphonic acid derivative with a unique mechanism of action inhibiting bacterial cell wall synthesis, has re-emerged as a potential therapeutic option for UTIs due to its broad-spectrum activity and oral availability.
Objective:
To determine the fosfomycin susceptibility pattern among Enterobacteriaceae isolates obtained from urine samples in a tertiary care hospital.
Methods:
This study was conducted in the Department of Microbiology at a tertiary care hospital over a one-year period. A total of 11,763 urine samples were processed, of which 2,773 showed significant bacterial growth. Among these, 150 uropathogenic Enterobacteriaceae isolates were randomly selected. Organisms were identified using standard microbiological techniques and the VITEK 2 system. Fosfomycin susceptibility was assessed by Kirby–Bauer disc diffusion method according to CLSI guidelines. Minimum inhibitory concentration (MIC) was determined by E-test for selected isolates.
Results:
Escherichia coli (79.4%) was the predominant isolate, followed by Klebsiella species (18%), Proteus species (1.3%), and Citrobacter species (1.3%). All isolates demonstrated susceptibility to fosfomycin by disc diffusion. MIC values for tested isolates were within the sensitive range (<64 µg/ml).

Conclusion:
Fosfomycin exhibited excellent in vitro activity against uropathogenic Enterobacteriaceae. It may serve as an effective oral treatment option for UTIs, particularly in the era of increasing antimicrobial resistance.
Field Medical / Pharmacy
Published In Volume 7, Issue 1, January-February 2026
Published On 2026-02-28
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