Advanced International Journal for Research

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Volume 7 Issue 3
May-June 2026

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Optimization, Formulation and Evaluation of Captopril Sublingual Tablet by Direct Compression Method for the Management of Blood Pressure

Author(s) Mr. Siva Bharathi, K. Sundramoorthy, M. Sujitha
Country India
Abstract The purpose of this investigation was to formulate, develop and optimize of sublingual drug delivery for antihypertensive drug. Sublingual tablets of Captopril were formulated using mannitol (PVP K-30) as diluents. Sublingual tablet was prepared by direct compression technique as it is a cost-effective method. Sodium saccharin sweetening agent. Magnesium stearate (3% to 4%) as lubricants. Super disintegrants used are cross povidone, croscarmellose sodium, sodium starch glycollate sodium CMC as a disintegrant. The sublingual drug showed acceptable results in all studies such as thickness, strength, disintegration test time, surface pH and drug release are developed. Sublingual tablets of captopril can be successfully prepared by direct Compression method used using selected super disintegrants with Cross povidone 1.5%, 3%, 6%, Croscarmellose 1.5%, 3%, 6% and Sodium starch glycolate 1.5%, 3%, 6%, for the better patient compliance and effective therapy the relative efficiency of these super disintegrants to improve the disintegration and dissolution rate of tablets were found in order. The formulation F3 showed the fastest disintegration time of 43 seconds and drug release 99% in 10 minutes.
Keywords Sublingual drug delivery, Antihypertensive drug, Captopril, Mannitol.
Field Medical / Pharmacy
Published In Volume 7, Issue 3, May-June 2026
Published On 2026-06-22
DOI https://doi.org/10.63363/aijfr.2026.v07i03.6347
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